Medicament for the treatment of burns



' Patented Oet. 1936 I Q It 3 UNITED STATES PATENT OFFICE MEDICAMENT FOR THE TREATMENT OF BURNS Russel J. Fosbinder, Short Hills, N. 1., assignor to The Maltbie Chemical Company, Newark, N. 1., a corporation of New Jersey No Drawing. Application January I; 1935, Serial No. 705

4 Claims. (CL 16'l63) This invention relates to medicaments or No. 1765, and also with that kno as Nopco dressings for the treatment of burns by the ap- CT 2F.

plication of tannic acid, the value of which for The relative amounts of the two oils needed the purpose is now widely recognized. One obto give a. desired easy emulsification can be read- 5 ject of the invention is to provide a tannic acid ily found by trial, but it can be said that in gen- 5' medicament, preferably in the form of a noneral, using Nopco oil No. 1216 (sperm) and Nopdrying ointment which can be easily applied to co oil CT 2F (petroleum oil) or acid Turkey-red the injured surface with the assurance that the oil, a ratio, by weight, of about 3:2 has been tannic 'acidwill be quickly. efiective. Another .fo'und satisfactory.

object is to provide a tannic acid ointment which An important advantage of the use of the mix- 10 will permit bandages to be removed from the time of sulphonated oils is that the resulting l burned area without pain or injury to the unmenstruum can carry a large enough amount derlying tissues. Afurther object is to provide a of bland ingredients, solid and liquid, to protannic acid ointment which can itself be reduce an ointment of smooth texture, of summoved from the burned surface by the use of cient softness for easy application, and yet of 15 water alone. To these and other ends the insufflcient viscosity to remain in 'place well at the vention comprises the novel composition of matbody temperature of the burned surface,and ter hereinafter described. still leave the ointment readily emulsifiable; and

An important feature of the invention is the this without using a large amount of the emuluse of a base or menstruum which is readily sifiable menstruum. Thus the bland ingree 2o emulsifiable, in water, preferably spontaneousdients,consisting of, say, neutral white parafly, so that an ointment which contains a wax fin oil of medium viscosity, white wax, and solid will not be repelled by a watery exudate of the paraflin,may constitute more than fifty per burned surface but will diffuse in the same and cent of the whole ointment, by weight, and the thereby bring the tannic acid quickly into consulphonated oil menstruum no more than fif- 25 tact with the injured tissue. The'mcst effective teen per cent, and Still give d a nt h v n emulsifying agent for the purpose is sulphonated the desirable therapeutic and physical properoil, and I have found that for the best results the ties referred to. Using the three bland ingreinterfacial surface tension of the oil-wax and dientsnamed, with the sulphonated oil ranging water interface should be well below 0.5 dyne from about 12:9 25 per cent and a wax (bees- 30 per centimeter at about 65 C. I have also found wax and solid 'paraflin) content of about 23 per that the desired low interfacial surface tension Cent, the paraflln oil may vary from about 30 is best obtained by the use of a mixture of sulto 40 per c n depending on e viscosity phonated oils, of different surface activities, in sired. If white wax is used without solid p such proportions that the net tension, so to fin a little borax, say .75 to 1 per cent, may be 35 speak, is such as will give the desired capability added to assist in emulsiflcation, but borax tends of easy, preferably spontaneous, emulsiflcation. t make t Ointment, gritty when Solid Paraffin Particularly good results have been obtained in is Present that direction by the use of a sulphonated oil Another advantage of the emulsiflable mencontaining a substantial amount of higher fatty ltruum or base is that if the ointment carries an 40 (wax) alcohol or alcohols, with only a small antiseptic the latter will also be brought into the amount of glycerol or giyceride, for instance most. efiective contact with the injured tissues, sulphonated sperm oil, of which the oil on the along with the tannic acid. So, also, a local market with the trade name Nopco No, 1216 anesthetic or analgesic. As an antiseptic a 4,5 is a good example. The sulphonated sperm oil creosote or phenolic derivative may be used to should be neutral.- The other oil may be a suladva ta p a y amyl m t cresol, a d as phonated petroleum oil, preferably about the an analgesicIprefer p-ethyl aminobenzoate, also same as ordinary glycerin in viscosity, or a sulknown as benzocaine, but any other compatible phonated vegetable oil, for example sulphonated substance of like properties may be used for the castor oil (commonly known as Turkey-red oil) purpose. 50 which contains a relatively large amount of glyc- A further advantage of the quick emulsifying eride and little if any of the higher alcohols. property of the ointment is that it makes a rela- When Turkey-red oil is employed it may be acid tively small tannic acid content as effective as a in reaction. For the second oil good results have much larger amount in an unctuous dressing of been obtained with the grade known as Nopco the usual character. If the ointment emulsifies 66 Gay.

readily in the aqueous exudate of the burned surface the tannic acid is brought quickly into con! tact with the injured tissues and tanning occurs rapidly. On the other hand, if the emulsification is slow, only the tannic acid in the contiguous layer of the ointment reaches the burned surface quickly, so that unless this layer carries a relatively large amount of tannic acid the desired tanning is delayed. With a sulphonated oil content of about 15 per cent and bland ingredientsvabout 55 per cent, a tannic acid content of 5 of an aqueous solution of about percent concentration. A relatively low water content, say 15 to per cent, is' desirable, as the water is then so well surrounded by the unctuous or oily material that the loss of water .by evaporation after the dressing is applied to the burn is minimized and the ointment does not become dry or stiff.

The preferred formula for theointment is the following, which has been found to be thoroughly efficient:

. I Y Percent sulphonated oil-- Neutral sperm'oil. 8.6 Neutral petroleum oil or acid 14.85 Turkey-red bi] 6.25 Bland ingredients- 1' White paraffin oil, medium 33 Solid 'parailln, melting point v I 55.9 60 C 13.9 White wax (beeswax) 9. f Tannic acid, technical '17 Water 21.2 Amyl meta cresol, 0.04 p-ethyl aminobenzoate (benzo- 1.04 caine).. -Q 1 V In compounding the ointment the sulphonated oil component bland ingredients are heated together to about 0., with stirring.

-When the mix is homogenous thev 'amyl meta cresol is stirred in,.after which thetannic acid solution, at about 0., is-added slowly, with constant stirring. When the mass has partly cooled the benzocaine is added, the stirring being continued until the ointment has cooled to about 30 C., after which it is allowed to set.

The ointment may be packaged in collapsible be employed if the blackening incident to simultaneous contact with metal and air is not objectionable. I

It is to be understood that the invention is not limited to the specific details described above but may be embodied inother forms without departure from its spirit as defined by the following claims:

I claim:

1. An ointment for the treatment of burns, containing tannic acid in aqueous solution, and a sulphonated oil menstruum comprising neutral sulphonated sperm oil and neutral sulphonated petroleum oil in the ratio, by weight, of about 3:2, and in total amount to render the ointment spontaneously diflusible in water.

2. An ointment for the treatment of burns, containing tannic acid in aqueous solution, and

a sulphonated oil menstruum comprising neutral sulphonated sperm oil and acid sulphonated castor oil in the ratio, by weight, of about 3:2, and in total amount adapted to render the ointment spontaneously diflusible in water.

3. A tannic acid ointment for the treatment of burns, which contains tannic acid in aqueous solution, and which also contains a sulphonated oil menstruum, giving an oil-water interfacial surface tension less than 0.5 dyne per centimeter,

in amount rendering the ointment spontaneously difl'usible into water, and which ointment contains an ointment base. v

4. A tannic acid ointment for the treatment.

of burns, which contains tannic acid in aqueous solution, in a menstruum containing sulphonated oils of different oil-water interfaclal surface tensions, proportioned to give together an oil-water interfacial surface tension less than 0.5 dyne per centimeter and in-amount rendering the ointment spontaneously diflusible in water, one of said oils containing a higher fatty alcohol and the other substantially free from such alcohols, and which ointment contains an ointment base.

- RUSSEL J. FOSBINDER. 

